NOT KNOWN DETAILS ABOUT PKRRATING

The activated enzyme then phosphorylates its important substrate, the translational initiation element eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to some conserved loved ones of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in response to various stimuli12, triggering the built-